Proactive - Interviews for investors

Sona Nanotech CMO discusses THT's potential to enhance immunotherapy efficacy

Episode Summary

Sona Nanotech Inc chief medical officer Dr Carman Giacomantonio takes Proactive's Stephen Gunnion through the company’s latest findings related to its targeted hyperthermia therapy (THT), which he described as showing “very enabling immunogenic” effects in recent experiments. The THT platform works by delivering controlled heat to the core of a tumour, triggering a natural cell death response and activating the body's immune system. Giacomantonio explained that this process exposes tumour proteins to immune cells, increasing the chance that they will be recognised and attacked. He noted that “all cancer cells have this kind of evolutionary quality” of resisting cell death, but THT stresses the cells enough to induce it. These latest experiments build on data first shared in December, with increased sample sizes confirming the reproducibility of the results. According to Giacomantonio, tumours treated with saline or checkpoint inhibitors alone continued to grow, while those exposed to THT and the immune modulator PD1 showed complete inhibition or reduction in growth. Looking ahead, he said the company plans to expand testing to demonstrate systemic immune responses, with the goal of treating metastatic cancers by targeting a single tumour site. Visit Proactive's YouTube channel for more company updates. Don’t forget to give this video a like, subscribe to the channel, and enable notifications so you never miss future content. #SonaNanotech #CancerTherapy #TargetedHyperthermia #Immunotherapy #BiotechNews #TumourTreatment #CancerResearch #MedicalInnovation #PD1Inhibitor #MetastaticCancer #HealthcareTech #OncologyBreakthrough